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Pharmaceutical Purified water

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Pharmaceutical purified water plays a central role in drug production, widely used as a solvent, ingredient, and equipment cleaning agent. Its quality is directly linked to the final quality of drugs and patient safety. Purified water is an essential raw material in the pharmaceutical production process, and its quality can directly impact both drug quality and safety. Strict microbial control of purified water systems is a core requirement of Good Manufacturing Practice (GMP). Among the various microbial control methods, ultraviolet (UV) disinfection and ozone (O3) disinfection are widely used due to their respective characteristics.

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UV disinfection devices offer flexibility and can be installed at various key points in a purified water system:

UV Total Organic Carbon (TOC) Reduction Device


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    Installed in the polishing unit of purified water preparation to protect subsequent units from organic contamination or to further remove residual organic matter.

UV Residual Chlorine Removal Unit

    Installed after the activated carbon filter and before the reverse osmosis membrane, it removes residual chlorine from the raw water or pretreatment process to prevent oxidation and damage to the reverse osmosis membrane.

UV Ozone Decomposition Unit

    After ozone disinfection, residual ozone in the water needs to be removed before the point of use. Ultraviolet light effectively catalyzes the decomposition of ozone, converting it to oxygen, preventing residual ozone from affecting subsequent processes or the final product.

Ozone Disinfection

    Ozone is primarily used for microbial control in purified water storage and distribution systems, particularly for the prevention and removal of biofilms. High-concentration ozone water is regularly injected into the system and circulated for a period of time to kill microorganisms within the system (including storage tanks and pipe linings) and destroy any biofilms that have formed.

    ·Continuous Low-Concentration Disinfection: A low concentration of ozone (e.g., tens of ppb) is maintained in the purified water storage tanks and distribution system to continuously inhibit microbial growth and biofilm formation.

    Ozone disinfection has a strong inactivating effect on bacteria, bacterial spores, viruses, and fungi. Ozone has a certain solubility in water, and as a gas, it can theoretically diffuse into every corner of a water system, including areas difficult to reach with traditional liquid disinfectants, such as tank headspaces and valve blind spots. This allows ozone to achieve a more comprehensive range of effects when used for system-wide disinfection, compared to ultraviolet light, which is only effective on the water flow.

    In pharmaceutical purified water systems, a single disinfection technology often cannot perfectly address all challenges. Ultraviolet (UV) and ozone (O3) each have unique advantages and limitations. Combining them to form a synergistic strategy is a common and effective method in the industry to improve microbial control and optimize system performance.

    This combined approach uses ozone as the primary system disinfectant and UV for ozone removal and terminal protection.


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